ctcRbase

Entry Detail

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General Information

Database ID: SKCM04995 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RASA1 Full Name: RAS p21 protein activator 1 Category: mRNA Synonyms: CM-AVM|CMAVM|GAP|PKWS|RASA|RASGAP|p120|p120GAP|p120RASGAP Chromosome: chr5 Strand: + Coordinate: Start Site(bp): 87267888 End Site(bp): 87391931 Gene Summary: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012] External Links: Ensembl ID: ENSG00000145715 HGNC ID: HGNC:9871 Entrez Gene: 5921

Expression Profile of RASA1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES NO YES hsa-miR-1271-5p YES NO YES hsa-miR-129-5p YES NO YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-132-3p YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-144-3p YES NO YES hsa-miR-145-5p YES YES YES hsa-miR-153-3p YES YES YES hsa-miR-182-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-188-5p YES NO YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-204-5p YES YES NO hsa-miR-206 YES YES YES hsa-miR-211-5p YES YES NO hsa-miR-212-3p YES YES YES hsa-miR-21-5p YES NO YES hsa-miR-218-5p YES YES NO hsa-miR-223-3p YES YES YES hsa-miR-24-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-31-5p YES YES YES hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-335-5p YES YES YES hsa-miR-338-3p YES YES YES hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-342-3p YES YES YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-375 YES YES NO hsa-miR-376a-3p YES YES YES hsa-miR-376b-3p YES YES YES hsa-miR-377-3p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-384 YES YES NO hsa-miR-421 YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-448 YES NO YES hsa-miR-454-3p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-495-3p YES YES YES hsa-miR-496 YES YES NO hsa-miR-590-5p YES NO YES hsa-miR-613 YES YES YES hsa-miR-873-5p YES YES YES hsa-miR-96-5p YES NO YES Display: