ctcRbase

Entry Detail

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General Information

Database ID: SKCM04996 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RANBP2 Full Name: RAN binding protein 2 Category: mRNA Synonyms: ADANE|ANE1|IIAE3|NUP358|TRP1|TRP2 Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 108719481 End Site(bp): 108785811 Gene Summary: RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000153201 HGNC ID: HGNC:9848 Entrez Gene: 5903

Expression Profile of RANBP2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-1297 YES YES NO hsa-miR-133a-3p YES YES NO hsa-miR-133b YES YES NO hsa-miR-137 YES YES YES hsa-miR-142-5p YES NO YES hsa-miR-153-3p YES YES YES hsa-miR-196a-5p YES YES YES hsa-miR-196b-5p YES YES YES hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-204-5p YES YES YES hsa-miR-205-5p YES NO YES hsa-miR-211-5p YES YES YES hsa-miR-217 YES NO YES hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-22-3p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-382-5p YES YES NO hsa-miR-411-5p YES NO YES hsa-miR-448 YES YES YES hsa-miR-487a-3p YES NO YES hsa-miR-488-3p YES YES NO hsa-miR-655-3p YES NO YES hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO hsa-miR-9-5p YES YES YES hsa-miR-98-5p YES YES YES Display: