ctcRbase

Entry Detail

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General Information

Database ID: SKCM05164 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ASCC1 Full Name: activating signal cointegrator 1 complex subunit 1 Category: mRNA Synonyms: ASC1p50|CGI-18|SMABF2|p50 Chromosome: chr10 Strand: - Coordinate: Start Site(bp): 72096032 End Site(bp): 72217134 Gene Summary: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] External Links: Ensembl ID: ENSG00000138303 HGNC ID: HGNC:24268 Entrez Gene: 51008

Expression Profile of ASCC1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1224-5p YES NO YES hsa-miR-144-3p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-187-3p YES YES NO hsa-miR-191-5p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-320a NO YES YES hsa-miR-320b NO YES YES hsa-miR-320c NO YES YES hsa-miR-320d NO YES YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-543 YES YES NO Display: