ctcRbase

Entry Detail

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General Information

Database ID: SKCM05987 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PTPN1 Full Name: protein tyrosine phosphatase, non-receptor type 1 Category: mRNA Synonyms: PTP1B Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 50510321 End Site(bp): 50585241 Gene Summary: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] External Links: Ensembl ID: ENSG00000196396 HGNC ID: HGNC:9642 Entrez Gene: 5770

Expression Profile of PTPN1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES NO YES hsa-miR-129-2-3p YES NO YES hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-140-3p YES NO YES hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-192-5p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-206 YES YES YES hsa-miR-211-5p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-215-5p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-22-3p YES YES YES hsa-miR-224-5p YES YES NO hsa-miR-29a-3p YES NO YES hsa-miR-29b-3p YES NO YES hsa-miR-29c-3p YES NO YES hsa-miR-31-5p YES YES NO hsa-miR-329-3p YES YES YES hsa-miR-362-3p YES YES YES hsa-miR-485-5p YES YES NO hsa-miR-613 YES YES YES hsa-miR-655-3p YES NO YES Display: