ctcRbase

Entry Detail

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General Information

Database ID: SKCM06345 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SPAG1 Full Name: sperm associated antigen 1 Category: mRNA Synonyms: CILD28|CT140|HEL-S-268|HSD-3.8|SP75|TPIS Chromosome: chr8 Strand: + Coordinate: Start Site(bp): 100157906 End Site(bp): 100259278 Gene Summary: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000104450 HGNC ID: HGNC:11212 Entrez Gene: 6674

Expression Profile of SPAG1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-101-3p YES YES NO hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-1271-5p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-140-5p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-28-5p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-375 YES YES NO hsa-miR-379-5p YES YES NO hsa-miR-454-3p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-708-5p YES YES NO hsa-miR-93-5p YES YES NO hsa-miR-96-5p YES YES NO hsa-miR-98-5p YES YES NO Display: