ctcRbase

Entry Detail

---



General Information

Database ID: SKCM06347 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PRCP Full Name: prolylcarboxypeptidase Category: mRNA Synonyms: HUMPCP|PCP Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 82823502 End Site(bp): 82970584 Gene Summary: This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] External Links: Ensembl ID: ENSG00000137509 HGNC ID: HGNC:9344 Entrez Gene: 5547

Expression Profile of PRCP Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-1271-5p YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-206 YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-328-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-613 YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-93-5p YES YES NO hsa-miR-96-5p YES YES NO Display: