ctcRbase

Entry Detail

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General Information

Database ID: SKCM06458 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PACS1 Full Name: phosphofurin acidic cluster sorting protein 1 Category: mRNA Synonyms: MRD17|SHMS Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 66070363 End Site(bp): 66244747 Gene Summary: This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000175115 HGNC ID: HGNC:30032 Entrez Gene: 55690

Expression Profile of PACS1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7b-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-miR-138-5p YES NO YES hsa-miR-143-3p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-24-3p YES NO YES hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-370-3p YES NO YES hsa-miR-423-5p YES NO NO hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-485-5p YES YES YES hsa-miR-665 YES NO YES Display: