| ncRNA Symbol: | COMP |
| Full Name: | cartilage oligomeric matrix protein |
| Category: | mRNA |
| Synonyms: | EDM1|EPD1|MED|PSACH|THBS5|TSP5 |
| Chromosome: | chr19 |
| Strand: | - |
| Coordinate: | | Start Site(bp): | 18782773 | End Site(bp): | 18791314 |
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| Gene Summary: | The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016] |
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