ctcRbase

Entry Detail

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General Information

Database ID: SKCM06886 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: BAX Full Name: BCL2 associated X, apoptosis regulator Category: mRNA Synonyms: BCL2L4 Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 48954815 End Site(bp): 48961798 Gene Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000087088 HGNC ID: HGNC:959 Entrez Gene: 581

Expression Profile of BAX Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-29a-3p NO YES YES hsa-miR-29b-3p NO YES YES hsa-miR-29c-3p NO YES YES hsa-miR-346 YES YES NO hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-506-3p YES YES NO Display: