ctcRbase

Entry Detail

---



General Information

Database ID: SKCM07014 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DMPK Full Name: DM1 protein kinase Category: mRNA Synonyms: DM|DM1|DM1PK|DMK|MDPK|MT-PK Chromosome: chr19 Strand: - Coordinate: Start Site(bp): 45769717 End Site(bp): 45782552 Gene Summary: The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016] External Links: Ensembl ID: ENSG00000104936 HGNC ID: HGNC:2933 Entrez Gene: 1760

Expression Profile of DMPK Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-1-3p YES YES YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-15a-5p YES NO NO hsa-miR-15b-5p YES NO NO hsa-miR-16-5p YES NO NO hsa-miR-182-5p YES YES NO hsa-miR-195-5p YES NO NO hsa-miR-206 YES YES YES hsa-miR-214-3p YES NO NO hsa-miR-424-5p YES YES NO hsa-miR-450a-5p YES YES NO hsa-miR-491-5p YES YES YES hsa-miR-497-5p YES NO NO hsa-miR-503-5p YES NO NO hsa-miR-613 YES YES YES Display: