ctcRbase

Entry Detail

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General Information

Database ID: SKCM07166 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ATF1 Full Name: activating transcription factor 1 Category: mRNA Synonyms: EWS-ATF1|FUS/ATF-1|TREB36 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 50763710 End Site(bp): 50821122 Gene Summary: This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010] External Links: Ensembl ID: ENSG00000123268 HGNC ID: HGNC:783 Entrez Gene: 466

Expression Profile of ATF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-1271-5p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-138-5p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-145-5p YES YES YES hsa-miR-153-3p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-329-3p YES NO NO hsa-miR-340-5p YES YES NO hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-362-3p YES NO NO hsa-miR-371a-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-448 YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-9-5p YES YES YES hsa-miR-96-5p YES YES NO Display: