ctcRbase

Entry Detail

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General Information

Database ID: SKCM07172 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DDHD1 Full Name: DDHD domain containing 1 Category: mRNA Synonyms: PA-PLA1|PAPLA1|SPG28 Chromosome: chr14 Strand: - Coordinate: Start Site(bp): 53036745 End Site(bp): 53153282 Gene Summary: This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria, while depletion of the gene results in mitochondrial tubule elongation. Deletion of this gene in male mice caused fertility defects, resulting from disruption in the organization of the mitochondria during spermiogenesis. In humans, mutations in this gene have been associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease, or, familial spastic paraparesis (FSP). This inherited disorder is characterized by progressive weakness and spasticity of the legs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] External Links: Ensembl ID: ENSG00000100523 HGNC ID: HGNC:19714 Entrez Gene: 80821

Expression Profile of DDHD1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES NO YES hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-128-3p YES NO YES hsa-miR-142-5p YES NO YES hsa-miR-144-3p YES NO YES hsa-miR-17-5p YES YES YES hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-302a-3p YES NO YES hsa-miR-302b-3p YES NO YES hsa-miR-302c-3p YES NO YES hsa-miR-302d-3p YES NO YES hsa-miR-302e YES NO YES hsa-miR-329-3p YES NO NO hsa-miR-340-5p YES NO YES hsa-miR-362-3p YES NO NO hsa-miR-372-3p YES NO YES hsa-miR-373-3p YES NO YES hsa-miR-376a-3p YES NO YES hsa-miR-376b-3p YES NO YES hsa-miR-519d-3p YES YES YES hsa-miR-520a-3p YES NO YES hsa-miR-520b YES NO YES hsa-miR-520c-3p YES NO YES hsa-miR-520d-3p YES NO YES hsa-miR-520e YES NO YES hsa-miR-520f-3p YES NO YES hsa-miR-532-5p YES NO YES hsa-miR-655-3p YES NO YES hsa-miR-93-5p YES YES YES Display: