ctcRbase

Entry Detail

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General Information

Database ID: SKCM07404 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CDH1 Full Name: cadherin 1 Category: mRNA Synonyms: Arc-1|BCDS1|CD324|CDHE|ECAD|LCAM|UVO Chromosome: chr16 Strand: + Coordinate: Start Site(bp): 68737225 End Site(bp): 68835548 Gene Summary: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015] External Links: Ensembl ID: ENSG00000039068 HGNC ID: HGNC:1748 Entrez Gene: 999

Expression Profile of CDH1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-143-3p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-199a-5p YES YES NO hsa-miR-199b-5p YES YES NO hsa-miR-217 YES NO YES hsa-miR-219a-2-3p YES NO YES hsa-miR-219a-5p YES YES NO hsa-miR-22-3p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-296-3p YES YES NO hsa-miR-326 YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-338-3p YES YES YES hsa-miR-339-5p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-361-5p YES NO YES hsa-miR-362-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-495-3p YES YES YES hsa-miR-599 YES YES NO hsa-miR-9-5p YES NO YES hsa-miR-98-5p YES YES NO Display: