ctcRbase

Entry Detail

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General Information

Database ID: SKCM07504 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: MRPL49 Full Name: mitochondrial ribosomal protein L49 Category: mRNA Synonyms: C11orf4|L49mt|MRP-L49|NOF|NOF1 Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 65122183 End Site(bp): 65127371 Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011] External Links: Ensembl ID: ENSG00000149792 HGNC ID: HGNC:1176 Entrez Gene: 740

Expression Profile of MRPL49 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-185-5p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-338-3p YES YES NO hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-455-5p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-590-5p YES YES YES hsa-miR-599 YES YES NO hsa-miR-873-5p YES YES NO Display: