ctcRbase

Entry Detail

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General Information

Database ID: SKCM07515 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: IRF1 Full Name: interferon regulatory factor 1 Category: mRNA Synonyms: IRF-1|MAR Chromosome: chr5 Strand: - Coordinate: Start Site(bp): 132481609 End Site(bp): 132490798 Gene Summary: The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000125347 HGNC ID: HGNC:6116 Entrez Gene: 3659

Expression Profile of IRF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-124-3p YES YES YES hsa-miR-130a-3p YES NO YES hsa-miR-130b-3p YES NO YES hsa-miR-132-3p YES NO YES hsa-miR-17-5p YES YES YES hsa-miR-205-5p YES NO YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-212-3p YES NO YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-24-3p YES YES YES hsa-miR-301a-3p YES NO YES hsa-miR-301b-3p YES NO YES hsa-miR-31-5p YES YES NO hsa-miR-335-5p YES YES YES hsa-miR-340-5p YES YES YES hsa-miR-377-3p YES YES NO hsa-miR-383-5p YES YES YES hsa-miR-454-3p YES NO YES hsa-miR-485-5p YES YES YES hsa-miR-506-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-625-5p YES NO NO hsa-miR-93-5p YES YES YES hsa-miR-9-5p YES NO YES Display: