ctcRbase

Entry Detail

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General Information

Database ID: SKCM08114 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: SYNGAP1 Full Name: synaptic Ras GTPase activating protein 1 Category: mRNA Synonyms: MRD5|RASA1|RASA5|SYNGAP Chromosome: chr6 Strand: + Coordinate: Start Site(bp): 33419661 End Site(bp): 33457541 Gene Summary: This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] External Links: Ensembl ID: ENSG00000197283 HGNC ID: HGNC:11497 Entrez Gene: 8831

Expression Profile of SYNGAP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-1-3p YES YES NO hsa-miR-140-5p YES YES NO hsa-miR-144-3p YES NO YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-190a-5p YES YES YES hsa-miR-190b YES YES YES hsa-miR-195-5p YES YES YES hsa-miR-206 YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-214-3p YES NO NO hsa-miR-219a-5p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-329-3p YES YES YES hsa-miR-331-3p YES NO YES hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-362-3p YES YES YES hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-379-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-409-5p YES NO YES hsa-miR-410-3p YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-519d-3p YES YES YES hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-541-3p YES NO NO hsa-miR-613 YES YES NO hsa-miR-654-5p YES NO NO hsa-miR-758-3p YES YES NO hsa-miR-7-5p YES YES NO hsa-miR-93-5p YES YES YES Display: