ctcRbase

Entry Detail

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General Information

Database ID: SKCM08133 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CCND3 Full Name: cyclin D3 Category: mRNA Synonyms: - Chromosome: chr6 Strand: - Coordinate: Start Site(bp): 41934933 End Site(bp): 42050357 Gene Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] External Links: Ensembl ID: ENSG00000112576 HGNC ID: HGNC:1585 Entrez Gene: 896

Expression Profile of CCND3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-1271-5p YES NO YES hsa-miR-130a-3p YES NO YES hsa-miR-130b-3p YES NO YES hsa-miR-138-5p YES YES YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-182-5p YES NO YES hsa-miR-195-5p YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-301a-3p YES NO YES hsa-miR-301b-3p YES NO YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-370-3p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-382-5p YES YES NO hsa-miR-421 YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-454-3p YES NO YES hsa-miR-497-5p YES YES NO hsa-miR-503-5p YES NO YES hsa-miR-505-3p YES YES YES hsa-miR-506-3p YES YES NO hsa-miR-96-5p YES NO YES Display: