ctcRbase

Entry Detail

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General Information

Database ID: SKCM08243 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PLCG1 Full Name: phospholipase C gamma 1 Category: mRNA Synonyms: NCKAP3|PLC-II|PLC1|PLC148|PLCgamma1 Chromosome: chr20 Strand: + Coordinate: Start Site(bp): 41136960 End Site(bp): 41196801 Gene Summary: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000124181 HGNC ID: HGNC:9065 Entrez Gene: 5335

Expression Profile of PLCG1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-1271-5p YES YES YES hsa-miR-129-5p YES YES YES hsa-miR-135a-5p YES YES YES hsa-miR-135b-5p YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-147a YES NO NO hsa-miR-149-5p YES NO YES hsa-miR-182-5p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-204-5p YES YES NO hsa-miR-205-5p YES YES NO hsa-miR-206 YES YES YES hsa-miR-211-5p YES YES NO hsa-miR-218-5p YES NO YES hsa-miR-299-3p YES YES NO hsa-miR-30a-5p YES NO YES hsa-miR-30b-5p YES NO YES hsa-miR-30c-5p YES NO YES hsa-miR-30d-5p YES NO YES hsa-miR-30e-5p YES NO YES hsa-miR-320a YES NO YES hsa-miR-320b YES NO YES hsa-miR-320c YES NO YES hsa-miR-320d YES NO YES hsa-miR-331-3p YES NO YES hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-369-3p YES NO YES hsa-miR-429 YES YES YES hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-455-5p YES YES YES hsa-miR-582-5p YES NO YES hsa-miR-613 YES YES YES hsa-miR-96-5p YES YES YES Display: