ctcRbase

Entry Detail

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General Information

Database ID: SKCM08244 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: KAT6B Full Name: lysine acetyltransferase 6B Category: mRNA Synonyms: GTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopf Chromosome: chr10 Strand: + Coordinate: Start Site(bp): 74825582 End Site(bp): 75032622 Gene Summary: The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] External Links: Ensembl ID: ENSG00000156650 HGNC ID: HGNC:17582 Entrez Gene: 23522

Expression Profile of KAT6B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-10a-5p YES YES YES hsa-miR-10b-5p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-134-5p YES YES NO hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-137 YES YES NO hsa-miR-138-5p YES YES YES hsa-miR-139-5p YES YES YES hsa-miR-141-3p YES YES YES hsa-miR-142-5p YES NO YES hsa-miR-144-3p YES YES YES hsa-miR-194-5p YES YES NO hsa-miR-200a-3p YES YES YES hsa-miR-206 YES YES YES hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-22-3p YES YES YES hsa-miR-24-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-328-3p YES YES YES hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-425-5p YES NO YES hsa-miR-433-3p YES YES NO hsa-miR-486-5p YES YES NO hsa-miR-487b-3p YES YES YES hsa-miR-613 YES YES YES Display: