ctcRbase

Entry Detail

---



General Information

Database ID: SKCM08296 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ALS2 Full Name: ALS2, alsin Rho guanine nucleotide exchange factor Category: mRNA Synonyms: ALS2CR6|ALSJ|IAHSP|PLSJ Chromosome: chr2 Strand: - Coordinate: Start Site(bp): 201700554 End Site(bp): 201781189 Gene Summary: The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] External Links: Ensembl ID: ENSG00000003393 HGNC ID: HGNC:443 Entrez Gene: 57679

Expression Profile of ALS2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-1297 YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-142-5p YES NO YES hsa-miR-143-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-145-5p YES YES NO hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-200a-3p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-411-5p YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-7-5p YES YES NO Display: