ctcRbase

Entry Detail

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General Information

Database ID: SKCM08316 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: NFYA Full Name: nuclear transcription factor Y subunit alpha Category: mRNA Synonyms: CBF-A|CBF-B|HAP2|NF-YA Chromosome: chr6 Strand: + Coordinate: Start Site(bp): 41072945 End Site(bp): 41099976 Gene Summary: The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000001167 HGNC ID: HGNC:7804 Entrez Gene: 4800

Expression Profile of NFYA Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-132-3p YES YES YES hsa-miR-140-3p YES NO YES hsa-miR-140-5p YES YES YES hsa-miR-148a-3p NO YES YES hsa-miR-148b-3p NO YES YES hsa-miR-152-3p NO YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-212-3p YES YES YES hsa-miR-22-3p YES YES YES hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-421 YES YES YES hsa-miR-429 YES YES YES hsa-miR-486-5p YES NO YES hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-520f-3p YES NO YES hsa-miR-653-5p YES YES NO Display: