ctcRbase

Entry Detail

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General Information

Database ID: SKCM08436 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: DAB2 Full Name: DAB2, clathrin adaptor protein Category: mRNA Synonyms: DOC-2|DOC2 Chromosome: chr5 Strand: - Coordinate: Start Site(bp): 39371675 End Site(bp): 39462300 Gene Summary: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] External Links: Ensembl ID: ENSG00000153071 HGNC ID: HGNC:2662 Entrez Gene: 1601

Expression Profile of DAB2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-124-3p YES YES YES hsa-miR-1271-5p YES YES YES hsa-miR-1297 YES YES YES hsa-miR-134-5p YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-145-5p YES YES YES hsa-miR-150-5p YES YES NO hsa-miR-153-3p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-187-3p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-32-5p YES YES NO hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-372-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-448 YES YES YES hsa-miR-506-3p YES YES YES hsa-miR-519d-3p YES YES YES hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO hsa-miR-93-5p YES YES YES hsa-miR-96-5p YES YES YES Display: