| ncRNA Symbol: | SMG9 | | Full Name: | SMG9, nonsense mediated mRNA decay factor | | Category: | mRNA | | Synonyms: | C19orf61|F17127_1|HBMS | | Chromosome: | chr19 | | Strand: | - | | Coordinate: | | Start Site(bp): | 43727992 | End Site(bp): | 43754990 |
| | Gene Summary: | This gene encodes a regulatory subunit of the SMG1 complex, which plays a critical role in nonsense-mediated mRNA decay (NMD). Binding of the encoded protein to the SMG1 complex kinase scaffold protein results in the inhibition of its kinase activity. Mutations in this gene cause a multiple congenital anomaly syndrome in human patients, characterized by brain malformation, congenital heart disease and other features. [provided by RefSeq, Jul 2016] | | External Links: | |
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