ctcRbase

Entry Detail

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General Information

Database ID: SKCM08666 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CDK9 Full Name: cyclin dependent kinase 9 Category: mRNA Synonyms: C-2k|CDC2L4|CTK1|PITALRE|TAK Chromosome: chr9 Strand: + Coordinate: Start Site(bp): 127785679 End Site(bp): 127790787 Gene Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000136807 HGNC ID: HGNC:1780 Entrez Gene: 1025

Expression Profile of CDK9 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1-3p YES YES YES hsa-miR-199a-5p YES YES NO hsa-miR-199b-5p YES YES NO hsa-miR-206 YES YES YES hsa-miR-224-5p YES YES YES hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-365a-3p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-613 YES YES YES hsa-miR-653-5p YES YES NO hsa-miR-874-3p YES YES NO Display: