ctcRbase

Entry Detail

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General Information

Database ID: SKCM08672 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PCGF2 Full Name: polycomb group ring finger 2 Category: mRNA Synonyms: MEL-18|RNF110|ZNF144 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 38733897 End Site(bp): 38749817 Gene Summary: The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000277258 HGNC ID: HGNC:12929 Entrez Gene: 7703

Expression Profile of PCGF2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES YES hsa-miR-107 YES YES YES hsa-miR-124-3p YES YES NO hsa-miR-133a-3p YES YES NO hsa-miR-133b YES YES NO hsa-miR-138-5p NO YES YES hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-329-3p YES NO NO hsa-miR-33a-5p YES YES NO hsa-miR-362-3p YES NO NO hsa-miR-384 YES YES NO hsa-miR-506-3p YES YES NO Display: