ctcRbase

Entry Detail

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General Information

Database ID: SKCM08720 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: CDKN1B Full Name: cyclin dependent kinase inhibitor 1B Category: mRNA Synonyms: CDKN4|KIP1|MEN1B|MEN4|P27KIP1 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 12715058 End Site(bp): 12722371 Gene Summary: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014] External Links: Ensembl ID: ENSG00000111276 HGNC ID: HGNC:1785 Entrez Gene: 1027

Expression Profile of CDKN1B Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-122-5p YES YES NO hsa-miR-1271-5p YES YES NO hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-150-5p YES YES NO hsa-miR-152-3p YES YES YES hsa-miR-155-5p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-190a-5p YES YES YES hsa-miR-190b YES YES YES hsa-miR-194-5p YES YES NO hsa-miR-196a-5p YES YES YES hsa-miR-196b-5p YES YES YES hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-218-5p YES YES NO hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-24-3p YES YES YES hsa-miR-323a-3p YES NO YES hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-377-3p YES YES YES hsa-miR-421 YES YES NO hsa-miR-429 YES YES YES hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-452-5p YES NO YES hsa-miR-455-5p YES YES YES hsa-miR-488-3p YES YES YES hsa-miR-495-3p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-520f-3p YES NO YES hsa-miR-543 YES YES NO hsa-miR-599 YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-877-5p YES NO YES hsa-miR-96-5p YES YES NO Display: