Entry Detail



General Information

Database ID:SKCM08731
Cancer Type:melanoma
Dataset:GSE38495
CTCs/CTM Isolation Method:immunomagnetic purification



Gene Information

ncRNA Symbol:MALT1
Full Name:MALT1 paracaspase
Category:mRNA
Synonyms:IMD12|MLT|MLT1|PCASP1
Chromosome:chr18
Strand:+
Coordinate:
Start Site(bp):58671386End Site(bp):58754477
Gene Summary:This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018]
External Links:
Ensembl ID:ENSG00000172175
HGNC ID:HGNC:6819
Entrez Gene:10892



Expression Profile of MALT1 Gene

 







Regulatory Relationship

mRNA targets:NA
miRNA targets:
miRNA NamePITAmiRandaRNAhybrid
hsa-miR-1297
YES
YES
NO
hsa-miR-146a-5p
YES
YES
NO
hsa-miR-146b-5p
YES
YES
NO
hsa-miR-147a
YES
NO
NO
hsa-miR-154-5p
YES
YES
NO
hsa-miR-190a-5p
YES
YES
NO
hsa-miR-190b
YES
YES
NO
hsa-miR-19a-3p
YES
YES
NO
hsa-miR-19b-3p
YES
YES
NO
hsa-miR-200b-3p
YES
YES
NO
hsa-miR-200c-3p
YES
YES
NO
hsa-miR-21-5p
YES
YES
NO
hsa-miR-26a-5p
YES
YES
NO
hsa-miR-26b-5p
YES
YES
NO
hsa-miR-300
YES
NO
YES
hsa-miR-329-3p
YES
YES
NO
hsa-miR-362-3p
YES
YES
NO
hsa-miR-365a-3p
YES
NO
YES
hsa-miR-371a-5p
YES
NO
YES
hsa-miR-374a-5p
YES
YES
NO
hsa-miR-381-3p
YES
NO
YES
hsa-miR-410-3p
YES
YES
NO
hsa-miR-429
YES
YES
NO
hsa-miR-495-3p
YES
YES
NO
hsa-miR-496
YES
YES
NO
hsa-miR-590-5p
YES
YES
NO
hsa-miR-653-5p
YES
YES
NO
hsa-miR-875-5p
YES
YES
NO
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