ctcRbase

Entry Detail

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General Information

Database ID: SKCM08746 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: BAP1 Full Name: BRCA1 associated protein 1 Category: mRNA Synonyms: HUCEP-13|UCHL2|hucep-6 Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 52401013 End Site(bp): 52410350 Gene Summary: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013] External Links: Ensembl ID: ENSG00000163930 HGNC ID: HGNC:950 Entrez Gene: 8314

Expression Profile of BAP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-1271-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-31-5p YES NO YES hsa-miR-370-3p YES YES NO hsa-miR-429 YES YES YES hsa-miR-505-3p YES YES YES hsa-miR-7-5p YES YES NO hsa-miR-96-5p YES YES NO Display: