ctcRbase

Entry Detail

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General Information

Database ID: SKCM08779 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RAPGEF5 Full Name: Rap guanine nucleotide exchange factor 5 Category: mRNA Synonyms: GFR|MR-GEF|REPAC Chromosome: chr7 Strand: - Coordinate: Start Site(bp): 22118238 End Site(bp): 22357144 Gene Summary: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] External Links: Ensembl ID: ENSG00000136237 HGNC ID: HGNC:16862 Entrez Gene: 9771

Expression Profile of RAPGEF5 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES NO YES hsa-miR-106b-5p YES NO YES hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-137 YES YES YES hsa-miR-141-3p YES YES NO hsa-miR-17-5p YES NO YES hsa-miR-182-5p YES YES YES hsa-miR-200a-3p YES YES NO hsa-miR-20a-5p YES NO YES hsa-miR-20b-5p YES NO YES hsa-miR-379-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-519d-3p YES NO YES hsa-miR-93-5p YES NO YES Display: