ctcRbase

Entry Detail

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General Information

Database ID: SKCM08851 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: B4GALT2 Full Name: beta-1,4-galactosyltransferase 2 Category: mRNA Synonyms: B4Gal-T2|B4Gal-T3|beta4Gal-T2 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 43978943 End Site(bp): 43991170 Gene Summary: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] External Links: Ensembl ID: ENSG00000117411 HGNC ID: HGNC:925 Entrez Gene: 8704

Expression Profile of B4GALT2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-148a-3p YES NO YES hsa-miR-148b-3p YES NO YES hsa-miR-152-3p YES NO YES hsa-miR-192-5p YES NO YES hsa-miR-215-5p YES NO YES hsa-miR-22-3p YES YES NO hsa-miR-296-3p YES YES NO hsa-miR-331-3p YES NO YES hsa-miR-335-5p YES YES NO hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-625-5p YES NO NO hsa-miR-653-5p YES YES NO hsa-miR-875-5p YES YES NO Display: