ctcRbase

Entry Detail

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General Information

Database ID: SKCM08885 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: NCOA2 Full Name: nuclear receptor coactivator 2 Category: mRNA Synonyms: GRIP1|KAT13C|NCoA-2|SRC2|TIF2|bHLHe75 Chromosome: chr8 Strand: - Coordinate: Start Site(bp): 70109762 End Site(bp): 70403805 Gene Summary: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] External Links: Ensembl ID: ENSG00000140396 HGNC ID: HGNC:7669 Entrez Gene: 10499

Expression Profile of NCOA2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-137 YES YES YES hsa-miR-1-3p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-185-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-18a-5p YES YES YES hsa-miR-18b-5p YES YES YES hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-206 YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-223-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-429 YES YES YES hsa-miR-433-3p YES YES NO hsa-miR-448 YES YES NO hsa-miR-505-3p YES YES YES hsa-miR-590-5p YES YES NO hsa-miR-613 YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-875-5p YES YES YES hsa-miR-876-5p YES YES NO Display: