ctcRbase

Entry Detail

---



General Information

Database ID: SKCM08948 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: BBS10 Full Name: Bardet-Biedl syndrome 10 Category: mRNA Synonyms: C12orf58 Chromosome: chr12 Strand: - Coordinate: Start Site(bp): 76344474 End Site(bp): 76348442 Gene Summary: This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and cognitive disability. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes. Mutations in this gene cause Bardet-Biedl syndrome type 10. [provided by RefSeq, Jan 2010] External Links: Ensembl ID: ENSG00000179941 HGNC ID: HGNC:26291 Entrez Gene: 79738

Expression Profile of BBS10 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1-3p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-206 YES YES NO hsa-miR-218-5p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-28-5p YES YES NO hsa-miR-300 YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-448 YES YES NO hsa-miR-613 YES YES NO hsa-miR-708-5p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: