ctcRbase

Entry Detail

---



General Information

Database ID: SKCM08961 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ARHGAP35 Full Name: Rho GTPase activating protein 35 Category: mRNA Synonyms: GRF-1|GRLF1|P190-A|P190A|p190ARhoGAP|p190RhoGAP Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 46918676 End Site(bp): 47005077 Gene Summary: The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000160007 HGNC ID: HGNC:4591 Entrez Gene: 2909

Expression Profile of ARHGAP35 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES NO NO hsa-miR-106a-5p YES NO YES hsa-miR-106b-5p YES NO YES hsa-miR-107 YES NO NO hsa-miR-130a-3p YES NO YES hsa-miR-130b-3p YES NO YES hsa-miR-138-5p YES NO YES hsa-miR-140-3p YES NO YES hsa-miR-142-5p YES NO YES hsa-miR-147a YES NO NO hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-17-5p YES NO YES hsa-miR-195-5p YES YES YES hsa-miR-20a-5p YES NO YES hsa-miR-20b-5p YES NO YES hsa-miR-300 YES YES YES hsa-miR-301a-3p YES NO YES hsa-miR-301b-3p YES NO YES hsa-miR-340-5p YES YES YES hsa-miR-375 YES NO YES hsa-miR-381-3p YES YES YES hsa-miR-410-3p YES NO YES hsa-miR-421 YES YES YES hsa-miR-424-5p YES YES YES hsa-miR-454-3p YES NO YES hsa-miR-455-3p YES NO YES hsa-miR-485-5p YES NO YES hsa-miR-497-5p YES YES YES hsa-miR-519d-3p YES NO YES hsa-miR-543 YES YES YES hsa-miR-93-5p YES NO YES Display: