| ncRNA Symbol: | TNNI3 | | Full Name: | troponin I3, cardiac type | | Category: | mRNA | | Synonyms: | CMD1FF|CMD2A|CMH7|RCM1|TNNC1|cTnI | | Chromosome: | chr19 | | Strand: | - | | Coordinate: | | Start Site(bp): | 55151767 | End Site(bp): | 55157773 |
| | Gene Summary: | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008] | | External Links: | |
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