ctcRbase

Entry Detail

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General Information

Database ID: SKCM09045 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PROS1 Full Name: protein S Category: mRNA Synonyms: PROS|PS21|PS22|PS23|PS24|PS25|PSA|THPH5|THPH6 Chromosome: chr3 Strand: - Coordinate: Start Site(bp): 93873033 End Site(bp): 93974066 Gene Summary: This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015] External Links: Ensembl ID: ENSG00000184500 HGNC ID: HGNC:9456 Entrez Gene: 5627

Expression Profile of PROS1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-205-5p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-375 YES YES NO hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-873-5p YES YES NO Display: