ctcRbase

Entry Detail

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General Information

Database ID: SKCM09064 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RUNX3 Full Name: runt related transcription factor 3 Category: mRNA Synonyms: AML2|CBFA3|PEBP2aC Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 24899511 End Site(bp): 24965121 Gene Summary: This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] External Links: Ensembl ID: ENSG00000020633 HGNC ID: HGNC:10473 Entrez Gene: 864

Expression Profile of RUNX3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-194-5p YES YES YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-210-3p YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-326 YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-330-5p YES YES NO hsa-miR-382-5p YES YES YES hsa-miR-454-3p YES YES YES hsa-miR-495-3p YES YES YES hsa-miR-519d-3p YES YES YES hsa-miR-625-5p YES NO NO hsa-miR-93-5p YES YES YES Display: