| ncRNA Symbol: | ERCC6 | | Full Name: | ERCC excision repair 6, chromatin remodeling factor | | Category: | mRNA | | Synonyms: | ARMD5|CKN2|COFS|COFS1|CSB|CSB-PGBD3|POF11|RAD26|UVSS1 | | Chromosome: | chr10 | | Strand: | - | | Coordinate: | | Start Site(bp): | 49455368 | End Site(bp): | 49539538 |
| | Gene Summary: | This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. [provided by RefSeq, Mar 2016] | | External Links: | |
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