ctcRbase

Entry Detail

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General Information

Database ID: SKCM09101 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: PSEN2 Full Name: presenilin 2 Category: mRNA Synonyms: AD3L|AD4|CMD1V|PS2|STM2 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 226870184 End Site(bp): 226896105 Gene Summary: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000143801 HGNC ID: HGNC:9509 Entrez Gene: 5664

Expression Profile of PSEN2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES NO hsa-miR-134-5p YES YES NO hsa-miR-183-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-217 YES YES NO hsa-miR-300 YES YES NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-370-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-506-3p YES YES NO Display: