| ncRNA Symbol: | REST |
| Full Name: | RE1 silencing transcription factor |
| Category: | mRNA |
| Synonyms: | DFNA27|GINGF5|HGF5|NRSF|WT6|XBR |
| Chromosome: | chr4 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 56907876 | End Site(bp): | 56966678 |
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| Gene Summary: | This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018] |
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