ctcRbase

Entry Detail

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General Information

Database ID: SKCM09131 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: GRB10 Full Name: growth factor receptor bound protein 10 Category: mRNA Synonyms: GRB-IR|Grb-10|IRBP|MEG1|RSS Chromosome: chr7 Strand: - Coordinate: Start Site(bp): 50590063 End Site(bp): 50793462 Gene Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010] External Links: Ensembl ID: ENSG00000106070 HGNC ID: HGNC:4564 Entrez Gene: 2887

Expression Profile of GRB10 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES NO NO hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-128-3p YES YES NO hsa-miR-1297 YES YES YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-141-3p YES YES NO hsa-miR-145-5p YES YES YES hsa-miR-15a-5p YES YES YES hsa-miR-15b-5p YES YES YES hsa-miR-16-5p YES YES YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-194-5p YES YES NO hsa-miR-195-5p YES YES YES hsa-miR-197-3p YES YES NO hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-19a-3p YES NO YES hsa-miR-19b-3p YES NO YES hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-214-3p YES NO NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-26a-5p YES YES YES hsa-miR-26b-5p YES YES YES hsa-miR-300 YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-31-5p YES YES YES hsa-miR-342-3p YES YES NO hsa-miR-34a-5p YES YES NO hsa-miR-34c-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-424-5p YES YES YES hsa-miR-429 YES YES NO hsa-miR-449a YES YES NO hsa-miR-449b-5p YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-455-3p YES NO YES hsa-miR-495-3p YES YES NO hsa-miR-497-5p YES YES YES hsa-miR-505-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-875-5p YES YES NO Display: