ctcRbase

Entry Detail

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General Information

Database ID: SKCM09134 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: ST5 Full Name: suppression of tumorigenicity 5 Category: mRNA Synonyms: DENND2B|HTS1|p126 Chromosome: chr11 Strand: - Coordinate: Start Site(bp): 8693351 End Site(bp): 8910951 Gene Summary: This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000166444 HGNC ID: HGNC:11350 Entrez Gene: 6764

Expression Profile of ST5 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-100-5p YES YES YES hsa-miR-124-3p YES NO YES hsa-miR-132-3p YES YES NO hsa-miR-140-5p YES YES YES hsa-miR-144-3p YES YES YES hsa-miR-146a-5p YES NO YES hsa-miR-146b-5p YES NO YES hsa-miR-193a-3p YES YES NO hsa-miR-193b-3p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-300 YES NO YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-378a-3p YES NO YES hsa-miR-381-3p YES NO YES hsa-miR-422a YES NO YES hsa-miR-486-5p YES YES YES hsa-miR-760 YES NO YES hsa-miR-874-3p YES YES YES hsa-miR-99a-5p YES YES YES hsa-miR-99b-5p YES YES YES Display: