ctcRbase

Entry Detail

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General Information

Database ID: SKCM09158 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: IL24 Full Name: interleukin 24 Category: mRNA Synonyms: C49A|FISP|IL10B|MDA7|MOB5|ST16 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 206897443 End Site(bp): 206904139 Gene Summary: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000162892 HGNC ID: HGNC:11346 Entrez Gene: 11009

Expression Profile of IL24 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1-3p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-205-5p YES YES NO hsa-miR-206 YES YES NO hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-324-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-346 YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-429 YES YES NO hsa-miR-613 YES YES NO Display: