| ncRNA Symbol: | HERC5 |
| Full Name: | HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
| Category: | mRNA |
| Synonyms: | CEB1|CEBP1 |
| Chromosome: | chr4 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 88457117 | End Site(bp): | 88506163 |
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| Gene Summary: | This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008] |
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