ctcRbase

Entry Detail

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General Information

Database ID: SKCM09215 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: HEY2 Full Name: hes related family bHLH transcription factor with YRPW motif 2 Category: mRNA Synonyms: CHF1|GRIDLOCK|GRL|HERP1|HESR2|HRT2|bHLHb32 Chromosome: chr6 Strand: + Coordinate: Start Site(bp): 125747664 End Site(bp): 125761269 Gene Summary: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000135547 HGNC ID: HGNC:4881 Entrez Gene: 23493

Expression Profile of HEY2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-153-3p YES YES YES hsa-miR-154-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-223-3p YES YES YES hsa-miR-22-3p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-302a-3p YES YES NO hsa-miR-302b-3p YES YES NO hsa-miR-302c-3p YES YES NO hsa-miR-302d-3p YES YES NO hsa-miR-302e YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-372-3p YES YES NO hsa-miR-373-3p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-448 YES YES YES hsa-miR-454-3p YES YES NO hsa-miR-520a-3p YES YES NO hsa-miR-520b YES YES NO hsa-miR-520c-3p YES YES NO hsa-miR-520d-3p YES YES NO hsa-miR-520e YES YES NO hsa-miR-655-3p YES NO YES Display: