ctcRbase

Entry Detail

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General Information

Database ID: SKCM09229 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: RNF139 Full Name: ring finger protein 139 Category: mRNA Synonyms: HRCA1|RCA1|TRC8 Chromosome: chr8 Strand: + Coordinate: Start Site(bp): 124474738 End Site(bp): 124487914 Gene Summary: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000170881 HGNC ID: HGNC:17023 Entrez Gene: 11236

Expression Profile of RNF139 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-101-3p YES NO YES hsa-miR-128-3p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-191-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-375 YES YES NO hsa-miR-421 YES YES NO hsa-miR-452-5p YES NO YES hsa-miR-495-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-875-5p YES YES NO Display: