ctcRbase

Entry Detail

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General Information

Database ID: SKCM09323 Cancer Type: melanoma Dataset: GSE38495 CTCs/CTM Isolation Method: immunomagnetic purification

Gene Information

ncRNA Symbol: TNFSF9 Full Name: TNF superfamily member 9 Category: mRNA Synonyms: 4-1BB-L|CD137L|TNLG5A Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 6530999 End Site(bp): 6535928 Gene Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008] External Links: Ensembl ID: ENSG00000125657 HGNC ID: HGNC:11939 Entrez Gene: 8744

Expression Profile of TNFSF9 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-182-5p YES YES NO hsa-miR-214-3p YES NO NO hsa-miR-24-3p YES NO YES hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-374b-5p NO YES NO hsa-miR-433-3p YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-98-5p YES YES YES Display: