exRNAdisease

General Information

Database ID:

exR0012320

RNA Name:

RPL11

RNA Type:

mRNA

Chromosome:

chr1

Starnd:

Coordinate:

Start Site(bp):

23691742

End Site(bp):

23696835

External Links:

Disease Information

Disease Name:	Down Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D004314
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Syndrome, Down//Mongolism//47,XY,+21//Trisomy G//47,XX,+21//Down's Syndrome//Downs Syndrome//Syndrome, Down's//Trisomy 21//Trisomy 21, Mitotic Nondisjunction//Down Syndrome, Partial Trisomy 21//Partial Trisomy 21 Down Syndrome//Trisomy 21, Meiotic Nondisjunction

Expression Detail

GEO ID:	GSE16176
Description:	Expression profiles of amniotic fluid from human fetuses with Down syndrome and euploid controls
Experimental Design:	Disease vs Control
Case Disease Type:	Down Syndrome
Case Disease SubType:	NA
Case Sample:	Down Syndrome
Control Sample:	Normal
Number of Case:	7
Number of Control:	7
Number of Samples:	14

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AFDN	chr6	167826922	167972023	+
AC139530.2	chr17	81703371	81720539	+
AIF1L	chr9	131096476	131123152	+
AKNA	chr9	114334156	114394405	-
AIMP2	chr7	6009255	6023834	+
ADORA2A	chr22	24417879	24442357	+
ACTG1	chr17	81509971	81523847	-
AIDA	chr1	222668013	222713210	-
ABCA3	chr16	2275881	2340746	-
ABL2	chr1	179099330	179229684	-
ACAA1	chr3	38103129	38137242	-
AKIRIN1	chr1	38991276	39006059	+
ACTR3	chr2	113890063	113962596	+
ACP1	chr2	264140	278283	+
AAAS	chr12	53307456	53324864	-
ADD2	chr2	70607618	70768225	-
AKR1B1	chr7	134442356	134459284	-
ACIN1	chr14	23058564	23095614	-
ABHD12	chr20	25294742	25390835	-
AC091167.2	chr15	90249556	90272208	+
AC245033.1	chr15	82536788	82573194	-
AC007192.1	chr19	18153158	18178117	+
ALDOA	chr16	30064164	30070457	+
ALDH4A1	chr1	18871430	18902724	-
AC010422.3	chr19	12643831	12648397	-
AC008770.2	chr19	11925075	11979290	+
ABRACL	chr6	139028745	139043302	+
ADM2	chr22	50481543	50486440	+
ADGRG1	chr16	57610652	57665580	+
ACTA1	chr1	229431245	229434098	-

miRNA targets:

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC005083.1	chr7	20217577	20221700	+
AC016876.2	chr17	7581964	7584086	-
AC040162.3	chr16	67882461	67886367	+
AC091564.7	chr11	6610883	6616594	-
AC092910.3	chr3	120094895	120136783	+
AC096992.2	chr3	136837338	136839021	-
AC104793.1	chr4	161378953	161388417	+
AC105339.2	chr15	82752884	82757208	+
AC108010.1	chr7	128574751	128626473	+
AC245014.3	chr1	145281116	145281462	+
AC245033.4	chr15	82533175	82540008	-
AL022311.1	chr22	37876148	37895563	+
AL023653.1	chrX	129794994	129796963	+
AL118516.1	chr22	46761894	46762563	-
AL133243.2	chr2	32521927	32523547	+
AL137782.1	chr13	75549773	75807120	+

Display:

Experiment Detail

GEO ID:	GSE16176
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	NA
RNA Extract protocol:	RNA was extracted from 10 mL AF with 30 mL TRIzol LS Reagent (Invitrogen, Carlsbad, CA) and 8 mL chloroform. After RNA extraction, RNA was purified and DNA was removed using the RNeasy® Maxi Kit, including the DNase step according to the manufacturer's protocol (QIAGEN, Valencia, CA). RNA was precipitated using 3M NaOAc and 100% ethanol, and 80% ethanol was added after 4 hours incubation at -20 °C. cDNA, synthesized from extracted RNA, was amplified and purified using the WT-Ovation™ Pico RNA Amplification System (NuGEN, San Carlos, CA) and the DNA Clean & Concentrator™-25 (Zymo Research, Orange, CA).
RNA library preparation protocol:	biotin Samples were labeled using the FL-Ovation™ cDNA Biotin Module V2 (NuGEN, San Carlos, CA).

Reference

PMID:	19474297
Title:	Functional genomic analysis of amniotic fluid cell-free mRNA suggests that oxidative stress is significant in Down syndrome fetuses
Author:	Slonim DK, Koide K, Johnson KL, Tantravahi U, Cowan JM, Jarrah Z, Bianchi DW
Journal:	Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9425-9.
Description:	To characterize the differences between second trimester Down syndrome (DS) and euploid fetuses, we used Affymetrix microarrays to compare gene expression in uncultured amniotic fluid supernatant samples.