exRNAdisease

General Information

Database ID:

exR0080592

RNA Name:

RPL28

RNA Type:

mRNA

Chromosome:

chr19

Starnd:

Coordinate:

Start Site(bp):

55385345

End Site(bp):

55403250

External Links:

Disease Information

Disease Name:	Fragile X Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D005600
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA

Expression Detail

GEO ID:	GSE83556
Description:	Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:	Disease vs Control
Case Disease Type:	Fragile X Syndrome
Case Disease SubType:	NA
Case Sample:	Fragile X Syndrome
Control Sample:	Normal
Number of Case:	22
Number of Control:	18
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
ABCD3	chr1	94418389	94518666	+
AC004832.3	chr22	30409255	30428990	+
AC004922.1	chr7	99325879	99394653	+
AC005258.1	chr19	2269525	2341172	+
AC006064.6	chr12	6556886	6607367	-
AC010323.1	chr19	8308283	8321379	-
AC010422.3	chr19	12643831	12648397	-
AC024592.3	chr19	5866171	5903787	-
AC073508.2	chr17	40627356	40665141	-
AC093525.2	chr16	2496032	2520218	+
AC104389.5	chr11	5254392	5678434	-
AC138811.2	chr16	18788063	18801519	-
ACAT2	chr6	159762045	159779112	+
ACLY	chr17	41866917	41930542	-
ACO2	chr22	41469117	41528989	+
ACTA1	chr1	229431245	229434098	-
ACTB	chr7	5527148	5563784	-
ACTG1	chr17	81509971	81523847	-
ADGRL1	chr19	14147743	14206187	-
AEBP2	chr12	19404045	19720801	+
AGRN	chr1	1020120	1056118	+
AHCY	chr20	34280268	34311802	-
AKAP13	chr15	85380571	85749358	+
AL049629.2	chr11	33698261	33722467	-
AL669918.1	chr6	32813767	32838822	-
ALAS1	chr3	52198086	52214327	+
ALDH2	chr12	111766887	111817532	+
ALDOA	chr16	30064164	30070457	+

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-6805-5p	chr19	55388186	55388207	+
hsa-miR-6805-3p	chr19	55388220	55388242	+

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC007952.4	chr17	19112000	19112636	-
AC010327.5	chr19	55216660	55221616	+
AC012360.3	chr2	105334027	105337475	-
AC016747.1	chr2	61141592	61144969	-
AC020928.2	chr19	36773712	36775908	-
AC026362.1	chr12	122975320	122982907	+
AC026471.1	chr16	31456711	31459736	-
AC091564.7	chr11	6610883	6616594	-
AC139149.1	chr17	81514047	81527776	+
AD000090.1	chr19	35557956	35581954	+

Display:

Experiment Detail

GEO ID:	GSE83556
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:	All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:	RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).

Reference