exRNAdisease

General Information

Database ID:

exR0083386

RNA Name:

TNPO2

RNA Type:

mRNA

Chromosome:

chr19

Starnd:

Coordinate:

Start Site(bp):

12699194

End Site(bp):

12724011

External Links:

Disease Information

Disease Name:	Fragile X Syndrome
Disease Category:	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:	D005600
Type:	Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:	Fragile X Syndromes//Syndrome, Fragile X//Syndromes, Fragile X//Marker X Syndrome//Marker X Syndromes//Syndrome, Marker X//Syndromes, Marker X//Mental Retardation, X-Linked, Associated With Marxq28//X-Linked Mental Retardation and Macroorchidism//X Linked Mental Retardation and Macroorchidism//Fragile X Mental Retardation Syndrome//Martin-Bell Syndrome//Martin Bell Syndrome//Syndrome, Martin-Bell//Fra(X) Syndrome//FRAXE Syndrome//FRAXE Syndromes//Syndrome, FRAXE//Syndromes, FRAXE//Mental Retardation, X-Linked, Associated With Fragile Site Fraxe//Fragile X-F Mental Retardation Syndrome//Mar (X) Syndrome//FRAXA Syndrome//FRAXA Syndromes//Syndrome, FRAXA//Syndromes, FRAXA

Expression Detail

GEO ID:	GSE83556
Description:	Global transcriptome dysregulation in second trimester fetuses with FMR1 expansions
Experimental Design:	Disease vs Control
Case Disease Type:	Fragile X Syndrome
Case Disease SubType:	NA
Case Sample:	Fragile X Syndrome
Control Sample:	Normal
Number of Case:	22
Number of Control:	18
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AAMP	chr2	218264123	218270257	-
ABCE1	chr4	145098288	145129524	+
ABL2	chr1	179099330	179229684	-
AC007040.2	chr2	70939318	70995336	-
AC010422.3	chr19	12643831	12648397	-
AC011462.1	chr19	41350853	41425001	+
AC011530.1	chr19	45779437	45785973	-
AC091167.2	chr15	90249556	90272208	+
AC092647.5	chr7	55887277	55955239	+
ACACA	chr17	37084992	37406836	-
ACADVL	chr17	7217125	7225266	+
ACTB	chr7	5527148	5563784	-
ADAM11	chr17	44758988	44781846	+
ADAM8	chr10	133262420	133276868	-
ADARB1	chr21	45073853	45226560	+
ADCK2	chr7	140672945	140696261	+
ADGRE5	chr19	14380501	14408725	+
ADGRG2	chrX	18989307	19122637	-
AGAP1	chr2	235494043	236131800	+
AGAP3	chr7	151085831	151144436	+
AGPAT5	chr8	6708642	6761503	+
AGRN	chr1	1020120	1056118	+
AL136295.4	chr14	24180395	24190416	-
ALDOA	chr16	30064164	30070457	+

miRNA targets:

miRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
hsa-miR-4787-5p	chr3	50675093	50675114	+

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC006538.1	chr19	2727743	2729327	-
AC011753.2	chr2	109594693	109605698	-
AC084125.2	chr8	144495458	144505444	-
AC109460.3	chr16	28974804	28990775	+
AD000090.1	chr19	35557956	35581954	+
AGAP11	chr10	86970741	87010126	+
AL049796.1	chr1	93847174	93848939	+
AL117379.1	chr20	62928621	62929297	-
AL136982.1	chr10	86992406	87010203	+

Display:

Experiment Detail

GEO ID:	GSE83556
Sample Source:	Amniotic Fluid
Source Fraction:	Supernatant
Platform:	GPL570
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	17063
Sample treatment protocol:	RNA was extracted from 5-15 mL amniotic fluid supernatant (centrifugation at 350g, 4C, 10, min).
RNA Extract protocol:	All samples were processed using the Qiagen Circulating Nucleic Acid kit with an on-column DNase digestion step to remove genomic DNA. The RNA was then purified and concentrated with the RNeasy MinElute Clean up kit and eluted in RNasefree water.
RNA library preparation protocol:	RNA was converted to cDNA and amplified using the Ovation Pico WTA kit V2 and then purified with the QIAquick PCR Purification kit. Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA)Samples were labeled using the Encore Biotin Module (NuGEN, San Carlos, CA).

Reference