exRNAdisease

Entry Detail

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General Information

Database ID: exR0087296 RNA Name: hsa-miR-103a-3p RNA Type: miRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 168560904 End Site(bp): 168560926 External Links: hsa-miR-103a-3p

Disease Information

Disease Name: Moyamoya Disease Disease Category: Nervous System Diseases MeSH ID: D009072 Type: Diseases Category/Nervous System Diseases Alias: Progressive Intracranial Occlusive Arteropathy (Moyamoya)//Moyamoya Syndrome//Moya-Moya Disease//Disease, Moya-Moya//Moya Moya Disease//Cerebrovascular Moyamoya Disease//Moyamoya Disease, Primary//Disease, Primary Moyamoya//Moyamoya Diseases, Primary//Primary Moyamoya Disease//Primary Moyamoya Diseases//Moyamoya Disease, Classic//Classic Moyamoya Disease//Disease, Classic Moyamoya//Moyamoya Disease, Secondary//Secondary Moyamoya Disease

Expression Detail

GEO ID: GSE100488 Description: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins Experimental Design: Disease vs Control Case Disease Type: Moyamoya Disease Case Disease SubType: NA Case Sample: Moyamoya Disease Control Sample: Normal Number of Case: 11 Number of Control: 10 Number of Samples: 21

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RCCD1 chr15 90954870 90963125 + CA12 chr15 63321378 63381846 - AMER1 chrX 64185117 64205708 - PLPP6 chr9 4662294 4665258 + ERG28 chr14 75649791 75660876 - SCAMP4 chr19 1905372 1926013 + DPP3 chr11 66480013 66509657 + AC011455.2 chr19 38915404 38949855 - UBN1 chr16 4846665 4882401 + TMX2 chr11 57712593 57740973 + RNF157 chr17 76142465 76240493 - NAA60 chr16 3443649 3486953 + MRPS2 chr9 135499984 135504673 + TSPYL2 chrX 53082367 53088540 + KLHL21 chr1 6590724 6614607 - TUBA1B chr12 49127782 49131397 - STEAP3 chr2 119223831 119265652 + MRPL3 chr3 131462212 131502983 - STK16 chr2 219245455 219250337 + ABCF2 chr7 151207837 151227166 - RPS6KA3 chrX 20149911 20267519 - DCAF7 chr17 63550477 63594279 + CNN2 chr19 1026586 1039068 + SRPK1 chr6 35832966 35921342 - ZNF697 chr1 119619377 119648266 - LYSMD2 chr15 51723011 51751585 - PODXL chr7 131500262 131558217 - EBP chrX 48521799 48528716 + RPS14 chr5 150442635 150449739 - PKM chr15 72199029 72231822 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000712 chr16 68208276 68225678 + hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0000652 chr15 90984737 90986710 + hsa_circ_0001472 chr5 36953719 36976504 + hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC003092.1 chr7 94022833 94066661 + AC018521.1 chr17 47945424 47981736 + AC021078.1 chr5 149494314 149504670 - AC021092.1 chr19 44103007 44113183 - AC093297.2 chr5 44826076 44828592 + AL137127.1 chr1 19072110 19075511 - FGD5-AS1 chr3 14920347 14948424 - H19 chr11 1995176 2001470 - LINC00294 chr11 33076149 33079454 + LINC00662 chr19 27681072 27794005 - LINC02035 chr3 122886941 122892416 + MIR503HG chrX 134543119 134546642 - NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - NUTM2B-AS1 chr10 79661394 79826594 - STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + TMEM147-AS1 chr19 35540738 35546029 - TTC28-AS1 chr22 27919376 28008581 + TTN-AS1 chr2 178521183 178779963 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE100488 Sample Source: Blood Source Fraction: Plasma Platform: GPL20712 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 291 Sample treatment protocol: Whole blood samples were collected into disodium ethylenediaminotetraacetate tubes, centrifuged (4 °C, 3000 rpm, 30 minutes) immediately for plasma. RNA Extract protocol: Total RNA was isolated from 200 uL of the pooled plasma using miRNeasy Serum/Plasma Kit (QIAGEN, Hilden, Germany). RNA library preparation protocol: Cyanine 3-pCp-labeled microRNA was prepared from 2-uL of total RNA isolated from 200-uL of plasma, using Agilent's miRNA Complete Labeling and Hyb Kit (part number 5190-0456).

Reference

PMID: 30157848 Title: Circulating miRNome profiling in Moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line Author: Uchino H, Ito M, Kazumata K, Hama Y, Hamauchi S, Terasaka S, Sasaki H, Houkin K Journal: BMC Med Genomics. 2018 Aug 29;11(1):72. Description: we employed a disease discordant monozygotic twin-based study design to unmask potential confounders.